scale-up methodology instruction, the key strategy to achieve industrial scale know-how

How to Scale Up Scientifically

www.pharmtech.com rational approach to scale-up has been used in the physical sciences for quite some time. This approach, called dimensional analysis, is a proven method of developing functional relationships that describe any given process in a dimensionless form to facilitate modeling and scale-up or scale-down. This short article reviews and demonstrates the dimensional analysis method as a...

Industrial scale-up of countercurrent chromatography: predictive scale-up.

This study describes how scale-up in countercurrent chromatography (CCC) can be simply predicted on a process scale CCC device by running a preliminary analytical-sized sample and having knowledge of the stationary-phase retention at scale-up conditions. Results have shown that simple experimentation can lead within a day to a process with the capability of several kilograms per day (tons per y...

Multi-scale methodology: a key to deciphering systems biology.

Presently, it is widely accepted complex systems couldn't be comprehended by studying parts in isolation without examining integrative and emergent properties, and system-level understanding thus has become the focus in biological science. However, it should also be noted that common systematic analysis was restricted to large-scale analysis at a certain level, while the facts that the nature o...

Scale-up methodology for pharmaceutical spray drying

Spray drying is presently one of the most interesting technologies in the pharmaceutical industry. The process shows a remarkable capability in manipulating powder/particle attributes such as size, morphology, density and level of residual solvents. This flexibility led to its application in a variety of powder formulations and advanced solid forms: from very fine powders for inhalation to larg...

“It’s About the Idea Hitting the Bull’s Eye”: How Aid Effectiveness Can Catalyse the Scale-up of Health Innovations

Background Since the global economic crisis, a harsher economic climate and global commitments to address the problems of global health and poverty have led to increased donor interest to fund effective health innovations that offer value for money. Simultaneously, further aid effectiveness is being sought through encouraging governments in low- and middle-income countries (LMICs) to strengthen...

Production Scale Up of Nanofibers: A Review